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KMID : 1007520110200061743
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Food Science and Biotechnology
2011 Volume.20 No. 6 p.1743 ~ p.1746
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Isolation and Identification of Compound from Dropwort (Oenanthe javanica) with Protective Potential against Oxidative Stress in HepG2 Cells
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Choi Hee-jung
You Yang-Hee
Hwang Kwon-tack
Lee Jeong-min
Chun Ji-Yeon
Chung Jin-Woong
Shim Sang-In
Park Chang-Soo
Jun Woo-Jin
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Abstract
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The protective effect of dropwort (Oenanthe javanica) was investigated in HepG2 cells under oxidative stress, and its active compound was identified. Compared to H2O2-alone treated cells, a drastic increase (35%) in protective activity was observed in the cells pretreated with 80% ethanol extract (OJE) of dropwort, suggesting that OJE possessed a potent hepatoprotectant. After a sequential procedure consisting of solvent-partitioning chromatography, TLC, and HPLC was conducted, the compound with proven hepatoprotective activity from OJE was isolated and identified as caffeic acid. Results indicated that caffeic acid in dropwort contributed to this herb’s protective profile against oxidative stress-induced liver damage.
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KEYWORD
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dropwort (Oenanthe javanica), HepG2 cell, caffeic acid, oxidative stress
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